THE IMPORTANCE OF CYTOKINES IN LIVER DISEASES
Abstract
THE IMPORTANCE OF CYTOKINES IN LIVER DISEASES
Zokirxojaev Sh.Y
Talibdjanova M.X
Tashkent Medical Academy, Tashkent, Uzbekistan
It is well known that liver cirrhosis is characterized by a pronounced fibrotic process, disruption of organ architecture, and the formation of regenerative nodules, leading to necrotizing inflammation. As a result, the internal veins of the liver and the portal vein become compressed, resulting in portal hypertension. In recent years, there has been an increase in research dedicated to the role of cytokines in the pathogenesis of liver cirrhosis and the development of disease complications. Under physiological conditions, cytokines regulate Ito cells, which are responsible for the main functions in organ fibrogenesis, specifically liver fibroblasts. In addition to producing profibrotic factors, Ito cells also produce antifibrotic factors, maintaining this balance. Antifibrotic factors include metalloproteinases such as collagenase, gelatinase, and stromelysin.
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References
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